Modern CNS Drug Discovery (inbunden, eng)

PART I - Introduction.- Merging the old and the new in modern CNS drug discovery.- Innovator, entrepreneur, leader: the tripartite drug discovery neuroscientist.- PART II - Innovation in the discovery of novel therapeutic approaches.- Drug discovery in CNS: finding a target for what?.- Neurogenomics with Application to Schizophrenia and Other Major Neuropsychiatric Diseases with Complex Heredity.- Safety and drug metabolism: towards NCE and first in human.- Conventional behavioral models and readouts in Drug Discovery: the importance of improving translation.- CNS medical devices: the various forms of non-invasive brain stimulation and their clinical relevance.- CNS medical devices: is non-invasive brain stimulation the low-hanging fruit?- PART III - Translational medicine & technology.- Electrophysiology: from molecule to cognition, from animal to human.- MRI in CNS drug development.- Positron Emission Tomography in drug development.- Application of cognitive test outcomes for clinical drug development.- Exciting research in the field of sexual psychopharmacology: treating patients with inside information.- A Paradigm Shift From DSM-5 to Research Domain Criteria: Application to Translational CNS Drug Development.- PART IV - Clinical Development and regulatory approval.- The special challenges of developing CNS drugs.- Phase 1 clinical trials in psychopharmacology.- Early development of erenumab for migraine prophylaxis.- Microdosing psychedelics as a promising new pharmacotherapeutic.- Partnering with the FDA.

Format	Inbunden
Omfång	283 sidor
Språk	Engelska
Förlag	Springer Nature Switzerland AG
Utgivningsdatum	2021-06-17
ISBN	9783030623500